Constantin fahlberg



UNITED STATES PATENT OEEicE,

OONS'IANTIN FAHLBERG, OF NEWV YORK, N. Y.

MEDICATED BENZOIC SULPHINIDE COMPOUND.

fiPECIPICATION forming part of Letters Patent Ne. 343,803, dated June15,1886.

Application filed September 26, 1885. Serial No. 178.284.

T0 aZZ whom it may concern.-

Be it known that I, OONSTANTIN FAHLBERG, of the city, county, and Stateof New York, have invented certain new and useful Improvements inMedicated Compounds, of which the following is a specification.

This invention relates to an improved medicated compound in theproduction of which the compound is employed for which Letters Patentwere granted to me, No. 319,082, dated June 2,1885, and to which thechemical name of benzoic sulphinide has been given, theinvention beingmore especially designed to prepare salts of benzoic sulphinide withquinine, cinchonine,chinidine, cinchonidine,morphine, and other organicalkaloids, and to neutralize thereby the disagreeable bitter taste ofthe same, so that said alkaloids can be taken directly without anyspecial vehicle, such as wafers, gelatine capsules, and the like.

The invention consists of a medicated com pound formed of a combinationof benzoic sulphinide with an organic alkaloid by first neutralizingsaid alkaloid with benzoic sulphinide in an aqueous or alcoholicsolution, and then crystallizing the resulting salt from the same.

I have discovered by a series of tests that benzoic sulphinide entersinto a chemical combination with organic alkaloids and forms salt-likecompounds with the same in the same manner as it forms a chemicalcombination with the alkalies, alkaline earths, and metals, as stated inmy prior patent referred to. Any

.organic alkaloid may be united with benzoic sulphinide, provided itshows the ordinary alkaline reaction of pure alkaloids.

In preparing salts of the alkaloids wit-h benzoic sulphinide, thealkaloid is first neutralized by benzoic sulphinide, either in anaqueous or alcoholic solution, until blue litmus-paper is not changed,upon which the salt of the alkaloid is obtained by crystallization orevaporation (Specimens) of the liquid. A neutral salt of benzoicsulphinide and the organic alkaloid is thereby formed, in which thebitter taste of the alka loid is almost entirely neutralized by thesweet taste of the benzoic sulphinide. Should it be desired to preparesalts of still sweeter taste, the neutral salts are changed to salts ofan acid character by adding an additional quantity of benzoicsulphinide, which is of special advantage in the case of the alkaloidshaving a greater degree of bitterness, as in the case of quinine and thealkaloids of the different species of cinchona, which may thereby bemore advantageously dispensed in pharmacy.

The effect of the compound formed of benzoic sulphinide and an organicalkaloid upon the human system has been found to be just as effective asthose of the sulphates and hydrochlorides of said alkaloids.

Having thus described my invention, I claim as new and desire to secureby Letters Patent- 1. A medicated compound consisting of benzoicsulphinide and an organic alkaloid, substantially as described.

2. A medicated compound consisting of benz'oic sulphinide and quinine,substantially as described.

3. The method herein described of making a medicated compound frombenzoic sulphinide and an organic alkaloid,which consists in dissolvingsaid benzoic sulphinide and the alkaloid in alcohol or water, and thencrystallizing the resulting salt from the solution, substantially as setforth. v

In testimony that I claim the foregoing as my invention I have signed myname in presence of two subscribing witnesses.

CONSTANTIN FAHLBERG.

Witnesses:

PAUL GOEPEL, SIDNEY MANN.

